Description
ZEISS Lattice SIM 3 is a structured illumination (SIM) super-resolution system optimized for fast 3D imaging of large biological samples.
The system delivers excellent optical sectioning, large fields of view, and gentle imaging conditions, making it ideal for multicellular specimens, tissues, and developing organisms.
Key Features
- Super-resolution imaging down to ~140 nm.
- Fast volumetric 3D imaging of large samples.
- Large field of view with flexible ROI zoom-in.
- Gentle live-cell imaging with low phototoxicity.
- Near-isotropic resolution with superior optical sectioning.
Technologies
- Lattice SIM: structured illumination for super-resolution.
- SIM Apotome: fast optical sectioning for large volumes.
- SIM² reconstruction: enhanced resolution and image quality.
- Leap mode: accelerated acquisition.
Applications
- Embryonic development studies.
- Organoids and 3D cell cultures.
- Tissue section imaging.
- Intercellular dynamics research.
- Multicellular systems biology.
Advantages
- Balanced system performance: large FOV and super-resolution.
- Speed: optimized for large-volume imaging.
- Gentle imaging: suitable for live samples.
- Flexibility: resolution vs speed modes.
- Versatility: live and fixed samples.
